… cholesterol, statins, has been shown to increase circulating PCSK9 levels, … geranylgeranyl
isoprenoids and hepatic Rap1a regulate both basal and statin-induced expression of PCSK9 …

… geranylgeranylation, which is inhibited by statins, we show that statin-treated hepatocytes
and the human liver … of LDLR and PCSK9 in statinmediated regulation of hepatocyte glucose …

… demonstrated that farnesyl or geranylgeranyl was attached to … results in basal transcription
of SREBP-regulated genes … component in the regulation of hepatic cholesterol metabolism but …

… Although statins are the most commonly used drugs to lower … -Epac2-Rap1 pathway as a
novel regulator of PCSK9 and … DIO mice with an adenovirus expressing the Rap1Gap which …

… from the isoprenoid geranylgeranyl pyrophosphate [10]. A … the hepatic system, as they are
a well-characterized hepatic model. … to determine the geranylgeranylation state of Rap1, one …

… PCSK9 may be directly related because expression of PCSK9 promotes the degradation of
hepatic … high-dose statins reduces plasma levels of LDL-C but increases levels of circulating …

… pcsk9 −/− mice and an anti-PCSK9 antibody to study the role of the LDL receptor (LDLR) and
ApoE in PCSK9-mediated regulation of … are needed to increase hepatic LDLR expression. …

… We show here that recombinant human PCSK9 expressed in … , purified human PCSK9
substantially reduced hepatic LDLR … , purified PCSK9 was added in the medium to control cells at …

… that inhibition of PCSK9 acts synergistically with existing treatments such as statins has led
… It is synthesized primarily by the liver and intestine as a 692-amino acid precursor (∼75 kDa) …

… suppression of liver PCSK9 mRNA and protein expression by OM … -triggered regulatory
network for PCSK9 expression that is … a statin with an OM mimetic inhibitor of PCSK9 expression. …